10 Best Chemicals and Pesticides To Kill Bed Bugs

Although there are plenty of chemicals and insecticides on the market that is used to kill bed bugs but here we will discuss top 10 best chemicals to kill bed bugs. You can simply use these chemicals and pesticides to kill bed bugs and their eggs permanently at home.

chemicals to kill bed bugs

Adult bed bugs are reddish-brown insects that are the size of an apple seed. They gorge on the blood of humans and animals. They only come out at night to attack the host when the host can’t defend itself. And, they remain hiding throughout the day. The problem with finding bed bugs is that they can fit themselves anywhere. Their flat body helps them to get into the tiniest cracks where they harbor during the day.

Removal of them at an early stage is very important since they can multiply. Also, they tend to travel to a new place and infest the new location. Taking help from the professionals can be costly as it might need several treatments. Though, you will have to take professional help if the infestation is severe. You can use multiple chemicals to remove their presence. Because it depends on the severity of the infestation which chemical to use.

In addition, EPA has registered more than 300 products to use against bed bugs. The consumers use most of the products themselves. But, EPA has registered a few chemicals that are only for professional use.

EPA has categorized these 300 products under seven chemical classes of pesticides. Those include Pyrethrin’s and Pyrethroids, Desiccants, Biochemicals, Pyrroles, Neonicotinoids, Insect growth regulators and Dichlorvos. EPA has registered Dichlorvos for a very narrow use pattern. For treating small enclosures, the professional’s use Dichlorvos as pest strips. In this article, we have tried to focus on first six above-mentioned chemicals. We have also given a narrow description of the usage. Each chemical class described below uses a different mode of action. The different mode of action is very effective in treating insecticide-resistant bed bugs. Follow the list of best pesticide for bed bugs.

10 Best Pesticides and Chemicals To Kill Bed Bugs

  • Pyrethrin’s and Pyrethroids
  • Desiccants
  • Diatomaceous earth
  • Boric acid
  • Silica gel
  • Biochemicals
  • Cold pressed neem oil
  • Pyrroles
  • Neonicotinoids
  • Insect growth regulators

Pyrethrin’s and Pyrethroids

Both compounds knock out the bed bugs in a similar manner. They are the professional bed bug chemicals used by exterminators for killing bed bugs. Most of the insecticides that are labeled for indoor use are made from a type of insecticide in the pyrethrin and pyrethroid family. And, they are also used to control other pests. Pyrethrins are derived from chrysanthemum flowers whereas pyrethroids are synthetic chemical insecticides. Both of them are toxic and can bring out bed bugs from their hiding places and destroy them. Inspectors inject a pyrethrum-based “flushing agent” into crevices and cracks to expose where bugs may be hiding.

But, there are bed bugs that are resistant to pyrethrins and pyrethroids. Studies show that the bed bugs have developed new ways to protect themselves from these insecticides. When the bed bugs that are resistant to pyrethrin’s and pyrethroids are treated using these two chemicals, they remove the bed bugs temporarily allowing them to move to find a new hiding place. In this situation, mixing the product with other products may work better. Switching to an entirely different chemical class would work even better. There are some pyrethroid pesticides that come in the form of a total release fogger.


Desiccants are proven to be a great tool when it comes to treating bed bugs. Unlike insecticides, the bed bugs cannot become resistant to desiccants. They work by absorbing the body fluid from the bug’s waxy shell causing them dehydrate. Although they work slowly they have a long-lasting effect. All the desiccants are not effective in killing bed bugs. Look for the EPA registered ones and the ones that are labeled to kill bed bugs.

Examples of desiccants include:

  • Diatomaceous earth
  • Boric acid
  • Silica gel

Diatomaceous earth

Diatomaceous earth is a non-toxic insecticide that is used to control pests at homes and gardens. It is one of the best bed bug extermination chemicals and strongest bed bug killer. It comes in the form of a fine crystalline powder and is also effective in killing fleas. This chemical works slowly on bed bugs and takes about 7 to 17 days to kill the bed bugs. And, it also hinders the crawling movement of the bed bugs.

Boric acid

Boric acid comes in the form of a bed bug killer powder which is derived from the chemical boron and water. It is white in color and slightly toxic in nature. It is considered as an effective and natural pest controller. This chemical is usually found as the key ingredient in most of the insecticides. Keep it away from children’s reach. Avoid applying boric acid to the places where it can come in direct contact with the skin.

Silica gel

Silica gel is a desiccant that is really cheap and an effective therapy to kill bed bugs. It does not occur naturally in its pure form. It reacts with oxygen to form silicon dioxide. Standard silica gel contains silicon dioxide and is transparent. The term gel is misleading and it comes in the form of beads or granules. It is hard and brittle. Non-standard types contain metal oxide or alumina.
Get some silica gel and grind it to a dust. Apply it over the mattresses and the cracks and crevices in the walls and furniture. They absorb the moisture from the bed bugs body causing them to dehydrate and ultimately die.


Cold pressed neem oil

Cold pressed neem oil is the only EPA-approved biopesticide for indoor use. They are effective in killing bed bugs but they need to be applied directly on the bugs. The problem with bed bugs is that they can harbor at the tiniest place and it is very difficult to find them. However, if you want to get rid of them completely you have no other choice. Cold pressed neem oil has been used by our ancestors to get rid of bed bugs. It is known its insecticidal and medicinal properties. Therefore, You can also boil some neem leaves in water and strain it and take a bath with that water to get rid of the itchiness that is caused by bed bugs.


Chlorfenapyr is the only pyrrole pesticide that is registered by EPA which is effective in killing bed bugs. It is a pro-insecticide which means that it metabolizes after it enters a living body. When applied to bed bugs it metabolizes into an active insecticide and reacts to form a new chemical. The new chemical interrupts the regular cellular activities of the cells of the bed bugs, causing its death.


These are the synthetic forms of nicotine. When applied to bed bugs, they act on the nicotinic receptors of the nervous system of the bed bugs. This causes the nerves to fire repeatedly until they fail. This is a unique method to kill bed bugs since they cannot become resistant to this method.

Insect growth regulators

These are the chemicals that mimic the growth hormones in bed bugs. Either they alter the growth of the bed bugs or else they alter the production of chitin. Chitin is the compound that bed bugs use to make their exoskeleton. Some growth regulators force the bed bugs to mature too fast, while others try to halt the development.

In addition, Their recent population has increased the awareness to cut down their population. Using chemicals to kill bed bugs is a well-known method. They are not just part of the developing world. They are very much present in the developed world as well.

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